According to reports the rapper was taken to Cedars-Sinai hospital in Los Angeles on Tuesday night by his bodyguards.
The 30-year-old appears to be feeling much better and tweeted to his 11million plus followers that he was on the mend.
'I'm fine. Thank u,' he wrote late on Wednesday morning.
In March Lil Wayne, real name Dwayne Carter, Jr. spent six days in intensive care after suffering multiple seizures.
He later explained in an interview that he is epileptic.
'The reason being for the seizures is just plain stress, no rest and overworking myself,' Dwayne said at the time. 'That's typical me, though.'
It is understood that the star fell ill while shooting Nicki Minaj's music video for High School, a track which he features on.
He was released the following day but suffered more seizures later that day and after being discovered by one of his bodyguards, was taken to hospital.
That was not the first time Lil Wayne has suffered seizures and back in October, he was onboard a flight from Texas to LAX when he started to convulse.
The flight was immediately diverted to Louisiana where he was admitted to hospital.